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Clifford D Wright Selected Research

6- ((3- ((4- (5- ((2- hydroxy- 2- (8- hydroxy- 2- oxo- 1,2- dihydroquinolin- 5- yl)ethyl)amino)pent- 1- yn- 1- yl)phenyl)carbamoyl)phenyl)sulfonyl)- 4- ((3- methoxyphenyl)amino)- 8- methylquinoline- 3- carboxamide

2/2017GS-5759, a Bifunctional β2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells.
8/2014The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β 2-adrenoceptor agonist in preclinical animal species.
4/2014The in vitro pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long acting β2-adrenoceptor agonist.

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Clifford D Wright Research Topics

Disease

6Chronic Obstructive Pulmonary Disease (COPD)
02/2017 - 03/2012
2Inflammation (Inflammations)
08/2014 - 03/2012
1Asthma (Bronchial Asthma)
08/2014
1Respiratory Tract Diseases (Respiratory Tract Disease)
08/2014
1Dehydration (Water Stress)
06/2013
1Lung Diseases (Lung Disease)
06/2013
1Pneumonia (Pneumonitis)
06/2013
1Fibrosis (Cirrhosis)
03/2012
1Airway Remodeling
03/2012
1Airway Obstruction (Choking)
03/2012
1Respiratory Hypersensitivity
08/2003
1Wounds and Injuries (Trauma)
12/2002

Drug/Important Bio-Agent (IBA)

4Phosphodiesterase 4 InhibitorsIBA
02/2017 - 03/2012
36- ((3- ((4- (5- ((2- hydroxy- 2- (8- hydroxy- 2- oxo- 1,2- dihydroquinolin- 5- yl)ethyl)amino)pent- 1- yn- 1- yl)phenyl)carbamoyl)phenyl)sulfonyl)- 4- ((3- methoxyphenyl)amino)- 8- methylquinoline- 3- carboxamideIBA
02/2017 - 04/2014
3Bronchodilator Agents (Bronchodilators)IBA
08/2014 - 04/2012
3RoflumilastIBA
04/2014 - 03/2012
1methylcholineIBA
08/2014
1AerosolsIBA
08/2014
1LipopolysaccharidesIBA
08/2014
1Cholinergic Antagonists (Anticholinergics)IBA
08/2014
1Type 4 Cyclic Nucleotide PhosphodiesterasesIBA
04/2014
1MacrolidesIBA
06/2013
1Leukocyte Elastase (Neutrophil Elastase)IBA
06/2013
12'-desoxy-9-erythromycylamineIBA
06/2013
1Anti-Bacterial Agents (Antibiotics)IBA
06/2013
1Epithelial Sodium ChannelsIBA
06/2013
1GoldIBA
04/2012
1Adrenergic Receptors (Adrenergic Receptor)IBA
04/2012
1CytokinesIBA
03/2012
1Extracellular Matrix ProteinsIBA
03/2012
1indacaterolIBA
03/2012
1Adrenergic Agonists (Adrenergic Receptor Agonist)IBA
03/2012
1Peptide Hydrolases (Proteases)FDA Link
08/2003
1Tryptases (Tryptase)IBA
08/2003
1Serine Proteases (Serine Protease)IBA
08/2003
1ProgranulinsIBA
12/2002
1GranulinsIBA
12/2002
1Pancreatic Elastase (Elastase)IBA
12/2002

Therapy/Procedure

3Therapeutics
08/2014 - 03/2012
1Nebulizers and Vaporizers (Inhaler)
08/2014